[CITATION][C] Role of urokinase and tissue activator in sustaining bleeding and the management thereof with EACA and AMCA
L Andersson, IM Nilsoon, S Colleen… - Annals of the New …, 1968 - Wiley Online Library
L Andersson, IM Nilsoon, S Colleen, JB Granstrand, B Melander
Annals of the New York Academy of Sciences, 1968•Wiley Online LibraryIn our excretion studies EACA was given in an amount of 100 mg/kg, a dose level used in
our long clinical studies. Based on comparative studies of the inhibition of streptokinase-
induced plasminogen activation by Melander ei al.(1965), and Andersson et al.(1965),
AMCA was given in an amount of 10 mg/kg. Our findings are presented in FIGURES 2 and 3.
The 24-hour urinary recovery of a single dose of EACA amounts to 71% after iv injection and
to 64% after oral administration. The corresponding figures for a single dose of AMCA are …
our long clinical studies. Based on comparative studies of the inhibition of streptokinase-
induced plasminogen activation by Melander ei al.(1965), and Andersson et al.(1965),
AMCA was given in an amount of 10 mg/kg. Our findings are presented in FIGURES 2 and 3.
The 24-hour urinary recovery of a single dose of EACA amounts to 71% after iv injection and
to 64% after oral administration. The corresponding figures for a single dose of AMCA are …
In our excretion studies EACA was given in an amount of 100 mg/kg, a dose level used in our long clinical studies. Based on comparative studies of the inhibition of streptokinase-induced plasminogen activation by Melander ei al.(1965), and Andersson et al.(1965), AMCA was given in an amount of 10 mg/kg. Our findings are presented in FIGURES 2 and 3. The 24-hour urinary recovery of a single dose of EACA amounts to 71% after iv injection and to 64% after oral administration. The corresponding figures for a single dose of AMCA are 91% after iv injection and 38.5% after oral administration. The half-life of both drugs in serum after a single iv injection is
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