Wallerian degeneration is a cascade of stereotypical events in reaction to injury of nerve
fibres. These events consist of cellular and molecular alterations, including macrophage
invasion, activation of Schwann cells, as well as neurotrophin and cytokine upregulation.
This review focuses on cellular and molecular changes distal to various types of peripheral
nerve injury which simultaneously contribute to axonal regeneration and neuropathic pain
induction. In addition to the stereotypical events of Wallerian degeneration, various types of …